The effect of omega-3 supplementation on serum inflammatory factors in hemodialysis patients

\ Yaser Salehi Najafabadi; ; Mojgan Mortazavi

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center	:	Isfahan University of Medical Sciences
Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	107798
Doc. No	:	T17145
Call number	:	WJ378,S163e,2016
Main Entry	:	Salehi Najafabadi, Yaser
Title & Author	:	The effect of omega-3 supplementation on serum inflammatory factors in hemodialysis patients\ Yaser Salehi Najafabadi
College	:	Schools, Medical
Date	:	, 2016
Degree	:	Speciality
field of study	:	Internal Medicine
Page No	:	16P.: tab
Note	:	This is a research dissertation with project ID: 293185
	:	یاسر صالحی نجف آبادی
Abstract	:	Background : the level of inflmatory factors such as tumor necrosis factor-alfa (TNF-α) and C-reactive protein (CRP) are increased in ESRD patients and And has been associated with increased mortality in these patients. Omega-3 is known as a regulator of inflammatory system. The aim of this study is evaluation of effect of omega-3 supplementation on TNF-α and CRP level in ESRD patients. Method :in This randomized controlled double-blind clinical trial,54 ESRD patients in tow hemodialysis centers of Isfahan university hospitals was evaluated. TNF-α and high specific-CRP (hs-CRP) was measured.In the experimental group ,Patients were treated with Omega-3 capsules (1 gram capsules- Making factory Zahravi- containing Eicosapentanoic 180mg and Dosahexanoic 120mg) three capsules per day ( 3g/day ) and the control group received placebo capsules were manufactured by the Zahravi with the same shape and size for 6 consecutive months.Results :There were no differences in CRP and TNF-α leveles in the start and the end of study between two groups (P > 0.05) . Conclusion : we conclude that the use of 3g of omega-3 per day for 6 consecutive months caused no significant effect on serum levels of TNF-α and CRP in the heamodialysis population.Further studies with larger numbers of patients and longer duration of treatment are recommended.
Descriptor	:	Renal Dialysis
	:	Fatty Acids, Omega-3
	:	Dietary Supplements
	:	Inflammation
Added Entry	:	Mortazavi, Mojgan, Thesis advisor
Translated Title Supplied by Cataloguer	:	بررسی تاثیر مکمل امگا 3 بر روی فاکتورهای التهابی در بیماران همودیالیز