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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 109154
doc. No : R3220
main entry : Kouhestani, Soheila Cllaborator
: Karimi , Somayeh Cllaborator
title & author : Frequency of celiac disease in children with growth and developmental retardation in central Iran, Isfahan [research project]/ Mohammad Hassan Emami; Soheila Kouhestani, Somayeh Karimi
Publication statement : IsfahanIsfahan University of Medical Sciences, Vice Chancellery for Research: 2012
Physical Description : [ Various Pages ]: tab.
Notes : Project ID: 82398
Contents : عنوان به فارسی: بررسی اپیدمیولوژیک، تشخیص، درمان و کنترل بیماری سلیاک ( در قالب پنج پروژه )
Summary or Abstract : Backgrounds:Iron deficiency anemia (IDA) is one of the well recognized presentations of celiac disease (CD). According to the lack of data from our population in this regard, we determined the prevalence of CD in patients presenting with IDA to see if it is worthwhile to do a precise screening for CD in such patients.Methods:This cross-sectional study was conducted on patients referred with IDA to Poursina Hakim Gastroenterology Clinic, Isfahan (IRAN). All included patients underwent upper gastrointestinal endoscopy and duodenal biopsy. Histopathological changes were assessed according to the Marsh classification. Also, patients were evaluated for IgA anti-tissue transglutaminase (t-TG) antibody with enzyme-linked immunosorbent assay (ELISA) technique. CD was defined as having Marsh II or above histopathology or being seropositive with Marsh I histopathology and having a good response to gluten free diet (GFD).Results:During the study, 130 patients with the mean age of 35.5±13.7 (67.7% female [20.4% post-menopausal]) were undergone seropathological studies. According to histopathological study and a clinical response to GFD, 13 patients (10%) were ultimately diagnosed with CD. Nine patients (6.9%) were seropositive, from which, five patients (3.8%) were ultimately diagnosed as CD cases. IgA anti-tTG became negative in all of these patients after six months of GFD.Conclusion:CD should be considered in any adult patient presenting with unexplained IDA, even if not accompanied with gastrointestinal symptoms. Routine duodenal biopsy performed during diagnostic upper gastrointestinal endoscopy is worthwhile in order to investigate for CD as an underlying cause of IDA in adult patients.
descriptor : Celiac Disease
: Duodenal Ulcer
: Anemia, Iron-Deficiency
: Transglutaminases
: Epidemiology
Originating Source : IRIsfahan University of Medical Science
publication type : p
 
 
 
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