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" Short-term effect of high-dose vitamin D on the level of interleukin 10 in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial "
/Fereshteh Ashtari
Hamid Zarkesh, Marjan Mansourian, Nafiseh Toghianifar , Akbar Forootan
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English
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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109229
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R3257
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| main entry
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Ashtari, , Fereshteh
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Short-term effect of high-dose vitamin D on the level of interleukin 10 in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial [research project]\ /Fereshteh AshtariHamid Zarkesh, Marjan Mansourian, Nafiseh Toghianifar , Akbar Forootan
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| Publication statement
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Isfahan: , Esfahan University of Medical Sciences, Vice Chancellery for Research, : 2015
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[ No Paging ]: .: diag
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Project ID: 192165
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| Contents
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عنوان به فارسی: مقایسه تاثیر دوز بالای ویتامین D3 با دوز معمول بر سطح اینترلوکین 10 در بیمران مبتلا به مولتیپل اسکروز طی یک کارآزمایی بالینی
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| Summary or Abstract
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Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Vitamin D has been related to the prevention of MS and to modulating its course. Recent studies have shown the safety of high-dose vitamin D in MS.OBJECTIVE:This study compared the effects of high-dose vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial.METHODS:Ninety-four patients with relapsing remitting MS (RRMS) were randomized into a treatment and a placebo group. Both groups received conventional MS treatment. The intervention group received 50,000 IU of vitamin D every 5 days for 3 months. IL-10 was measured at baseline and after 3 months.RESULTS:Serum levels of IL-10 were (median ± IQR): 12.58 ± 11.97 and 10.97 ± 9.97 pg/ml in the intervention and placebo groups, respectively, at baseline (p = 0.161); after 3 months, these levels were 13.76 ± 18.95 and 11.31 ± 19.63 pg/ml, respectively (p = 0.158). The IL-10 level increased significantly after receiving high-dose vitamin D for 3 months (β = 0.737, p = 0.015 and R2 = 0.91).CONCLUSION:IL-10 levels increased significantly in RRMS patients after taking high-dose vitamin D3 for 3 months. High-dose vitamin D might be useful in promoting an anti-inflammatory state in RRMS patients
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Multiple Sclerosis
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Cholecalciferol
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Interleukin-10
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Zarkesh, Hamid, Cllaborator
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Mansourian, Marjan, Cllaborator
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Toghianifar, Nafiseh, Cllaborator
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Forotan, Akbar, Cllaborator
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IRIsfahan University of Medical Science
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p
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