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" Association Study Between Metabolic Syndrome and rs8066560 Polymorphism in the Promoter Region of Sterol Regulatory Element-binding Transcription Factor 1 Gene in Iranian Children and Adolescents "
/ Roya Kelishadi , Modjtaba Emadi-Baygi, Parvaneh Nikpour
; Hajar Miranzadeh-Mahabadi
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English
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طرح تحقیقاتی/ پروژه لاتین
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109364
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R3213
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Kelishadi, , Roya
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, Emadi Baygi, , Modjtaba
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, Nikpour, , Parvaneh
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Association Study Between Metabolic Syndrome and rs8066560 Polymorphism in the Promoter Region of Sterol Regulatory Element-binding Transcription Factor 1 Gene in Iranian Children and Adolescents [research project]\ / Roya Kelishadi , Modjtaba Emadi-Baygi, Parvaneh Nikpour; Hajar Miranzadeh-Mahabadi
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| Publication statement
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Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2016
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[ No Paging ]: ,: tab
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Project ID: 190147
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| Contents
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عنوان به فارسی: بررسی توزیع فراوانی آللی پلی مورفیسم تک نوکلئوتیدی rs8066560 ژن SREBFIC در کودکان و نوجوانان مبتلا به سندرم متابولیک در مقایسه با گروه کنترل مراجعه کننده به مرکز درمانی کودکان بیمارستان الزهرا( س) اصفهان
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| Summary or Abstract
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Background:Metabolic syndrome (MetS) is a prevalent disorder in pediatric age groups, described by a combination of genetic and environmental factors. Sterol regulatory element-binding transcription factor 1 (SREBF-1) induces the expression of a family of genes involved in fatty acid synthesis. Moreover, dysregulation of miR-33b, which is located within the intron 17 of the SREBF-1 gene, disrupts fatty acid oxidation and insulin signaling, thus leading to MetS. The aim of the present study was to investigate the association between SREBF-1 rs8066560 polymorphism and MetS in Iranian children and adolescents.Methods:This study includes 100 MetS and 100 normal individuals aged 9–19 years. Anthropological and biochemical indexes were measured. The -1099G > A polymorphism was genotyped by TaqMan real-time polymerase chain reaction.Results:Significant differences were observed in anthropometric measurements and lipid profiles between MetS and normal children. There were no differences in the genotype frequencies or allele distribution for -1099G > A polymorphism between MetS and control groups. High-density lipoprotein cholesterol levels were significantly higher in the MetS GG group than in the A allele carrier group. The genotype AA controls had significantly increased cholesterol and low-density lipoprotein cholesterol levels than AG genotypes. By logistic regression using different genetic models, no significant association was observed between SREBF-1 rs8066560 polymorphism and the risk of MetS.Conclusions:We conclude that the -1099G > A variant on SREBF-1 gene associated with serum lipid profiles, however, it may not be a major risk factor for the MetS in Iranian children and adolescents.
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Metabolic Syndrome X
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Polymorphism, Single Nucleotide
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Sterol Regulatory Element Binding Proteins
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Child
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Adolescent
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Miranzadeh-Mahabadi , Hajar Cllaborator
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| Originating Source
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IRIsfahan University of Medical Science
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p
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