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" Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy "
\ Farzaneh Nikoobin
; Hamid Emami
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Isfahan University of Medical Sciences
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Latin Dissertation
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English
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| Record Number
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111709
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T18374
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WN250,N694d,2015
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| Main Entry
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Nikoobin, Farzaneh
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| Title & Author
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Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy\ Farzaneh Nikoobin
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Schools, Medical
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, 2015
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Specialty
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; Radiation Oncology
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No Paging: tab
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| Note
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This is a research dissertation with project ID: 391021
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فرزانه نیکوبین
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Electronical
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| Abstract
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Background: Radiation-induced discomfort is frequently observed during pelvic radiotherapy. Th is study was performed to determinethe eff ect of a green tea tablet to reduce the incidence of radiation-induced diarrhea and vomiting in patients with abdomen andpelvic malignancy. Materials and Methods: Th is randomized controlled clinical trial recruited 42 patients with abdomen and pelvicmalignancy considered for treatment with 50 Gy radiotherapy, randomly assigned to the green tea tablet 450 mg (n = 21) or placebogroup (n = 21) for 5 weeks. Acute gastrointesinal complications (Diarrhea and vomiting) were weekly assessed using Common ToxicityCriteria of the National Cancer Institute version 3.0 and functional living index emesis, respectively. Two-sample t-tests, Pearson’sChi-square, Mann-Whitney U-test, and Friedman were used for analysis. Results: Th ere was a signifi cant diff erence in frequencyof reported diarrhea between two groups of study at the end of study (P < 0.002). About 81% of patients in green tea group reportedno history of diarrhea at week 5. Th e treatment group have reported no history of severe diarrhea during radiotherapy. Th ere wasno signifi cant diff erence between two groups of study in frequency of vomiting throughout the study, but 9.5% of cases in placebogroup showed severe vomiting. Conclusion: Green tea contains a high concentration of catechins could be eff ective in decreasingthe frequency and severity of radiotherapy induced diarrhea. Green tea (450 mg/day) could be considered to be a safe for preventiondiarrhea and vomiting in patients undergoing pelvic or abdomen radiotherapy
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| Descriptor
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Radiotherapy
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Tea
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Diarrhea
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Pelvis
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| Added Entry
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Emami , Hamid Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر قرص چای سبز بر عارضه اسهال حاد، استفراغ و تهوع پس از رادیوتراپی شکم و لگن
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