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" Preventive Effect of Paracetamol and Dexamethasone on Nausea, Vomiting, and Pain after Laparoscopic Cholecystectomy under General Anesthesia and its Comparison with Controls "
\ Babak Haghanifar
; Gholamreza Khalili, Reyhank Talakoub
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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English
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| Record Number
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112368
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T18422
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| Main Entry
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Haghanifar, Babak
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| Title & Author
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Preventive Effect of Paracetamol and Dexamethasone on Nausea, Vomiting, and Pain after Laparoscopic Cholecystectomy under General Anesthesia and its Comparison with Controls\ Babak Haghanifar
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| College
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Schools, Medical
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| Date
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, 2017
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| Degree
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Specialty
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Anesthesiology
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| Page No
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12p.: tab
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| Note
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This is a research dissertation with project ID: 394552
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بابک حقانی فر
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Electronical
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| Abstract
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Objective: The currently used antiemetic drugs are not effective in all post-operative patients due to multifactorial origin of nausea and vomiting. Therefore, the present study was designed to evaluate the preventive effect of paracetamol on postoperative nausea and vomiting (PONV) in comparison with dexamethasone in patients undergoing elective laparoscopic cholecystectomy.Methods: Subjects in this double-blinded clinical trial were selected through the random sampling method and 105 patients with ASA I and II, aging 18-75 years, who were candidate for laparoscopic cholecystectomy were included in the study. The patients were randomly divided into three groups of paracetamol, dexamethasone, and control and were anesthetized with the same method. To induce anesthesia, they received thiopental sodium (6 mg/kg), fentanyl (2 µg/kg), atracurium (0.6 mg/kg), and lidocaine (1.5 mg/kg). Anesthesia was continued with oxygen (6 L/min), isoflurane (1.2-1.8%), and morphine (0.15 mg/kg). They also received 6 mL/kg/h ringer lactate. Patients information including age, gender, weight, length of anesthesia and surgery, length of stay in recovery room, length of extubation, the severity of nausea, and the frequency of vomiting were recorded and analyzed with SPSS.Results: The mean severity of nausea and vomiting in the recovery room at minutes 30, 45, and 60 had a significant difference between the groups (p<0.05). The satisfaction score at minutes 45 and 60 had a significant difference between the groups (p<0.05). But, the mean score of satisfaction of patients at minutes 15 and 30 was almost the same and had no significant difference between the three groups (p>0.05).Conclusion: The severity of nausea and vomiting was low in the paracetamol group and paracetamol was more effective than dexamethasone in terms of reducing the rate of nausea and vomiting.Keywords: paracetamol, dexamethasone, laparoscopic cholecystectomy
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Khalili, Gholamreza, Thesis advisor
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Talakoub, Reihanak, Thesis advisor
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