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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 112853
Doc. No : T18456
Main Entry : Tabesh, Elham
Title & Author : Premedication with benzodiazepines for upper gastrointestinal endoscopy: Comparison between oral midazolam and sublingual alprazolam\ Elham Tabesh
College : Schools, Medical
Date : , 2017
Degree : Speciality
field of study : Gastroenterology
Page No : 17 p.: tab
Note : This is a research dissertation with project ID: 395569
: الهام تابش
Note : Electronical
Abstract : Background: Premedication with orally administered benzodiazepines is effective in reducing anxiety and discomfort related to endoscopic procedures. We evaluated the efficacy and safety of oral midazolam in comparison to sublingual alprazolam as premedication for esophagogastroduodenoscopy (EGD). Materials and Methods: Adult candidates for diagnostic EGD received either oral midazolam (7.5 mg in 15 cc apple juice) or sublingual alprazolam (0.5 mg) 30 min before EGD. Procedural anxiety and pain/discomfort were assessed using 11-point numerical rating scales. Patients’ overall tolerance (using a four-point Likert scale) and willingness to repeat the EGD, if necessary, were also assessed. Blood pressure, heart rate, and arterial oxygen saturation were monitored from medication to 30 min after the procedure. Results: Patients experienced a similar reduction in procedural anxiety after medication with oral midazolam or sublingual alprazolam; mean (standard deviation [SD] of 1.86 [1.63] and 2.02 [1.99] points, respectively, P = 0.91). Compared to oral midazolam, pain/discomfort scores were lower with sublingual alprazolam; mean (SD) of 4.80 (3.01) versus 3.68 (3.28), P = 0.02. There was no significant difference between the two groups in patients’ tolerance, willingness to repeat the procedure, or hemodynamic events. Conclusion: Oral midazolam and sublingual alprazolam are equally effective in reducing EGD-related anxiety; however, EGD-related pain/discomfort is lower with alprazolam. Both benzodiazepines are equally safe and can be used as premedication for patients undergoing diagnostic EGD
Descriptor : Anxiety
: Midazolam
: Benzodiazepines
: Endoscopy, Gastrointestinal
: Premedication
: Alprazolam
Added Entry : Sebghatollahi, Vahid Thesis advisor
: Minakari , Mohammad , Consulting advisor
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Premedication with benzodiazepines for upper gastrointest...
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