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" Effect of Tetanus-diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-responder Individuals "
Maryam salehi
Abbas Haghighat, Hassan Salehi
Roya Taleban
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Isfahan University of Medical Science
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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113806
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| Doc. No
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T18621
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WC 536 ,S163e,2017
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| Main Entry
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salehi, , Maryam
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| Title & Author
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Effect of Tetanus-diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-responder Individuals \ Maryam salehi
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| College
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School Dentistry
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| Date
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2017
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| Degree
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DD
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| field of study
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Dentistry
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20p.
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Project ID:191049
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| Note
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Electronic
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| Abstract
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Conventional hepatitis B virus (HBV) vaccination fails to achieve efficient protection in about 5–10% of the world population. Hence, different strategies have been adopted to ameliorate HBV antibody titers. This study aimed to evaluate the concurrent application of tetanus-diphtheria (Td) and HBV vaccination on hepatitis B surface (HBs) antibody titer in low-responder healthy individuals.Methods:This was a randomized clinical trial, which was implemented among 140 of medical staff working as health-care workers assumed as low-responders. The subjects were randomly allocated to either control or interventional groups. The control and interventional groups received HBV recombinant vaccine while the latter group was also vaccinated through Td. Enzyme-linked immunosorbent assay was applied to measure HBs antibody (HBsAb) titers just before and 6 months after the last vaccination. All data were entered into SPSS software. Independent t-test, paired t-test, and Chi-square or Fisher's exact test were applied for data comparison.Results:Antibody titers of the subjects in the intervention and control groups soared from 49.08 ± 20.08 IU/L to 917.78 ± 204.80 IU/L and from 46.95 ± 18.55 to 586.81 ± 351.77 IU/L, respectively (both P < 0.001); nevertheless, by comparison with control group, variation of antibody titer in the interventional group was significantly higher (P < 0.001).Conclusions:Concurrent application of Td and HBV vaccine could effectively
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| Descriptor
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Hepatitis B vaccine
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low responders
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tetanus-diphtheria vaccine
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Haghighat , Abbas
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Salehi , Hassan
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Taleban, Roya
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Isfahan University of Medical Sciences
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| Translated Title Supplied by Cataloguer
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« بررسی پاسخ ایمنی به تزریق همزمان واکسن دیفتری-کزاز و هپاتیت B در افراد با پاسخ ناکافی به واکسن هپاتیت B در پرسنل بیمارستان الزهرا (س)»
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