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" Quantitative Polymerase Chain Reaction in Diagnosis of Pneumocystis Pneumonia "
\ Marzieh Pozveh
; Azar Baradaran, Mohsen Meidani
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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114044
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| Doc. No
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T19042
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| Main Entry
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Pozveh, Marzieh
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| Title & Author
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Quantitative Polymerase Chain Reaction in Diagnosis of Pneumocystis Pneumonia\ Marzieh Pozveh
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| College
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Schools, Medical
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| Date
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, 2018
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| Degree
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Speciality
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| field of study
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, Pathology
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| Page No
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11 p: tab
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| Note
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This is a research dissertation with project ID: 396115
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مرضیه پزوه
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Electronical
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| Abstract
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Introduction: Pneumocystis pneumonia (PCP) remains a serious cause of sickness and death in immunocompromised patients. Lung injury and respiratory impairment during pneumocystis pneumonia are mediated by marked inflammatory responses in the host to the organism. Quantitative PCR (qPCR) is more sensitive than microscopy for detecting Pj in BAL. The relevant threshold remains to be determined and may vary according to the underlying disease.Methods: All BAL samples were obtained from immunocompromised and non-immunocompro¬mised patients presenting with respiratory symp¬toms referred to the Department of infectious diseases of Alzahra Hospital, Isfahan, Iran. All statistical analyses were performed using SPSS (Statistical Package for the Social Sciences, Chicago, IL, USA) version 22. Results: 2 patients (12%) of immunocom-promised patients were positive for Pj. Among non-immunocompromised patients, 3 (8%) were posi¬tive for Pj. Fisher exact test demonstrated that Pj positivity was not significantly different between the two groups. The overall frequency of Pj positivity was estimated as 10%.Conclusion: 12% of immunocompromised patients and 8% of non-immunocompromised were colo¬nized by Pj which may progress to PJP or contami¬nate susceptible individuals.
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| Descriptor
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Real-Time Polymerase Chain Reaction
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Diagnosis
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Pneumocystis
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Pneumonia
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| Added Entry
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Baradaran, Azar , Thesis advisor
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Meidani , Mohsen , استاد راهنما
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