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" Comparative evaluation of the effect of propofol-ketamine and propofol-remifentanil for deep sedation and analgesia during painful procedures in 6 month to 14 year old children with acute lymphoblastic leukemia "
\ Sahar Ghanbardezfoli
; Hamidreza Shetabi , Mohammad Golparvar
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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English
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| Record Number
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114258
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| Doc. No
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T19083
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| Main Entry
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Ghanbardezfoli , Sahar
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Shetabi, Hamidreza , Thesis advisor
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| Title & Author
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Comparative evaluation of the effect of propofol-ketamine and propofol-remifentanil for deep sedation and analgesia during painful procedures in 6 month to 14 year old children with acute lymphoblastic leukemia\ Sahar Ghanbardezfoli
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| College
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Schools, Medical
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| Date
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, 2018
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| Degree
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MD
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| field of study
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, Medicine
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| Page No
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10 p.: tab
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| Note
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This is a research dissertation with project ID: 294148
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سحر قنبردزفولی
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Electronical
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| Abstract
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Objective: Comparing the effectiveness of two drug combinations of Propofol-Ketamine and Propofol-Remifentanil in children with acute lymphoblastic leukemia under bone marrow aspiration or biopsy and lumbar puncture.Methods: In a clinical trial, 81 children of 6 months to 14 years old with acute lymphoblastic leukemia who were candidates for lumbar puncture, bone marrow aspiration or biopsy were randomly divided into two groups of receiving Propofol-Ketamine and receiving Propofol-Remifentanil. In each group, hemodynamic indices, sedation, side effects, the onset of effectiveness and duration of remaining in the recovery room were measured and recorded. Data were analyzed using Chi square test, Mann-Whitney, independent t-test and Fisher’s exact test with a significant level of p<0.05.Results: The need for repeating drug’s dosage was significantly lower in the group receiving Propofol-ketamine than the other group (p=0.009). The mean of systolic blood pressure and arterial oxygen saturation at the end of the procedure was significantly lower in the Propofol-Remifentanil receiving group (respectively p=0.040 and p=0.001). During the procedure, the frequency of hypotension was significantly higher in the Propofol-Remifentanil receiving group (p=0.048). The recovery duration was reported significantly longer for the Propofol-Ketamine receiving group (p=0.004). Sedation indices, other hemodynamic indices and the onset on effectiveness had no significant difference between both groups (p>0.050).Conclusions: It seems that the combination of Propofol-Ketamine due to lower need for repetition of the drug dose and more hemodynamic stability could be a more appropriate combination in children especially in patients with unstable hemodynamics.
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| Descriptor
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Leukemia, Biphenotypic, Acute
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Propofol
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Ketamine
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Conscious Sedation
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Child
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Pain
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Golparvar, Mohammad استاد راهنما
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