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" Comparison of the incidence and severity of delirium and biochemical factors after CABG in patients with and without dexmedetomidine- A clinical trial study "
/ Shima Khamesipour
; Gholamreza Masoumi, Mojtaba Mansouri
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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114271
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| Doc. No
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T19087
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| Main Entry
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Khamesipour, Shima
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| Title & Author
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Comparison of the incidence and severity of delirium and biochemical factors after CABG in patients with and without dexmedetomidine- A clinical trial study/ Shima Khamesipour
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| College
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Schools, Medical
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| Date
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, 2018
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| Degree
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MD
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| field of study
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, Medicine
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| Page No
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16 p.: tab
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| Note
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This is a research dissertation with project ID: 395214
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شیما خامسی پور
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| Note
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Electronical
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| Abstract
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Introduction: One of the most common postoperative complications, such as open heart surgery, is delirium, which is responsible for increased mortality and morbidity. Therefore, it is necessary to find a way to cure this disease. Therefore, the purpose of this study was to evaluate the effect of dexmedetomidine administration on the prevention of delirium after coronary artery bypass graft surgery.Materials and Method: This study is a randomized, double blind clinical trial that was performed on 88 patients undergoing coronary artery bypass graft surgery (44 in the dexmedetomidine group and 44 in the control group) after being registered with IRCT20171104037209N1 code number. Patients were randomly divided into intervention and control groups. The intervention group was subcutaneously treated with doses of 1 μg / kg of dexmedetomidine for 10 minutes and 0.2-0.7 μg / kg in hour infusion was applied and The control group underwent normal saline infusion as a placebo. In both groups, the patients were treated with haloperidol (0.5 mg intramuscularly) in the event of delirium. Chi-square and ANOVA tests were used to compare the data. Results: The results of our study was performed on 88 patients with open heart surgery who were 72 (81.8%) males and 16 (18.18%) were female and their average age was 61.55 ± 8.4 years, showed that the administration of dexmedetomidine significantly decreased delirium (P = 0.04) and delirium intensity (P = 0.001). Moreover, the results of our study showed that patients treated with dexmedetomidine has more stability in laboratory variables and vital signs such as blood pressure, and also the duration of hospitalization in these patients was significantly lower than control group. (P = 0.002)Conclusion: Due to the high incidence of delirium after surgery, the diagnosis, screening and successful treatment of this disease by using dexmedetomidine after coronary artery bypass graft surgery Immediately after entering the ICU, it significantly reduces the incidence of delirium and cognitive impairment after coronary artery bypass graft surgery until it is separated from the ventilator
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| Descriptor
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Delirium
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Dexmedetomidine
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Postoperative Complications
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Coronary Artery Bypass
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| Added Entry
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Masoumi, Gholamreza , Thesis advisor
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Mansouri , Mojtaba , استاد راهنما
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