| Material Type
|
:
|
طرح تحقیقاتی/ پروژه لاتین
|
| Record number
|
:
|
51437
|
| doc. No
|
:
|
R2806
|
| main entry
|
:
|
Nilfrousihzadeh, Mohammad Ali
|
| title & author
|
:
|
Comparison between intralesional meglumine antimoniate and combination of trichloroacetic acid 50 ad intralesional meglumine antimoniate in the treatment of acute cutaneous leishmaniasis [Research Project]/Executer: Nilfrousihzadeh MA,Jaffary F, Derakhshan R, Haftbaradaran E
|
| Publication statement
|
:
|
Isfahan: Isfahan Medical University, Vice Chancellery for Research.
|
| Notes
|
:
|
Background: Cutaneous leishmaniasis (CL) is an endemic disease in Iran. Pentavalent antimonials including meglumine antimoniate (MA) still are the gold standard treatment. Based on potential induction of collagen synthesis and efficacy of TCA in the treatment of popular CL lesions, this study was designed to assess the efficacy of combined intralesional MA and TCA compared to MA alone for treatment of CL.Methods: 200 patients with confirmed CL were randomized into two treatment groups. Both groups received intralesional injection of MA twice a week until complete healing of the lesion or up to 8 weeks. In combination therapy group, TCA was applied to the lesions fortnightly up to week 8..
|
| Notes
|
:
|
Print
|
| Contents
|
:
|
Complete cure was achieved in 79.2 of MA treated patients and 85.7 patients of the combination therapy group (P>0.05). There was a significant difference in complete cure time between two groups with accelerated healing rate in the combination therapy group.
|
|
|
:
|
Conclusion
|
|
|
:
|
This study showed that combination therapy with intralesional MA and 50 TCA could accelerate the healing process of CL lesions compared to intralesional MA alone.
|
|
|
:
|
Topical 50 TCA could be suggested as an adjuvant therapy to decrease the healing time of the lesions in patients with cutaneous leishmaniasis.
|
| Originating Source
|
:
|
IRIsfahan University of Medical Sciences
|
| publication type
|
:
|
p
|
| Source
|
:
|
Vice Chancellery for Research
|