خط مشی دسترسی
پرسش و پاسخ
طرح تحقیقاتی/ پروژه لاتین
Nilfrousihzadeh, Mohammad Ali
title & author
Based Hydroalcoholic Extract Nigella Sativa 60 percent Compared to Honey Alone in Patients with Cutaneous Leishmaniasis receiving Intralesional Glucantime -Efficacy of Adding Topical Honey [Research Project]/Executer: Mohammad Ali Nilforoushzadeh1, Sayed Hossein Hejazi, Bidabadi, Fariba Jaffary-Hajar Zarkoob, Leila Shirani
Isfahan: Isfahan Medical University, Vice Chancellery for Research.
based topical Nigella sativa extract compared to topical honey in patients with cutaneous leishmaniasis receiving intralesional glucantime. peutic effects on improving wound healing, this study was designed to evaluate the efficacy of honey-inflammatory and antimicrobial effects of honey and Nigella sativa and their reported thera-Background: Based on the anti based hydroalcoholic Nigella sativa extract 60 versus 48 patients (64 ) in the other group. There was a significant difference between the healing rates of the two groups (P = 0.002). Conclusion: The efficacy of adjunct honey and Nigella sativa extract along with intralesional glucantime is more than that of honey alone in increasing the clinical cure, and decreasing the residual scar size and the required dose of glucantime. -Methods: In a prospective clinical trial, 150 patients with confirmed cutaneous leishmaniasis were selected and randomized into two groups. In each group, patients received topical honey or hydroalcoholic Nigella sativa extract 60 twice per day along with intralesional injection of glucantime once per week. The treatment continued until ulcers were completely healed or for a maximum of 12 weeks. Results: During 12 weeks, complete cure was achieved in 61 patients (81.3 ) treated with topical honey.
Complete cure was achieved in 79.2 of MA treated patients and 85.7 patients of the combination therapy group (P>0.05). There was a significant difference in complete cure time between two groups with accelerated healing rate in the combination therapy group.
This study showed that combination therapy with intralesional MA and 50 TCA could accelerate the healing process of CL lesions compared to intralesional MA alone.
Topical 50 TCA could be suggested as an adjuvant therapy to decrease the healing time of the lesions in patients with cutaneous leishmaniasis.
IRIsfahan University of Medical Sciences
Vice Chancellery for Research
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