| Material Type
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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51440
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| doc. No
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R2818
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| main entry
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Mahnam, Karim
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| title & author
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Theoretical studies of 1, 4- dihydropyridine 3, 5- dicarboxamides as possible inhibitors of Mycobacterium tuberculosis enoyl reductase [Research Project]/Executer: Karim Mahnam .Amir Sadeghi, Mehrdad Mohammadpour, Afshin Fassihi
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| Publication statement
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Isfahan: Isfahan Medical University, Vice Chancellery for Research.
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| Notes
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enzyme complexes to calculate the binding free energies of these ligands to the enzyme. All of the studied compounds stayed in the active site. An energetic analysis reveals that van der Waals share is more important than electrostatic in binding of all ligands to the active site. -acp reductase (InhA) from M. tuberculosis was studied by the docking method. Totally 230 ns molecular dynamics simulation was performed for 19 ligand-dicarboxamides to enoyl-dihydropyridine 3,5-The binding affinity of some novel 1,4.
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| Notes
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Print
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| Contents
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Complete cure was achieved in 79.2 of MA treated patients and 85.7 patients of the combination therapy group (P>0.05). There was a significant difference in complete cure time between two groups with accelerated healing rate in the combination therapy group.
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Conclusion
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This study showed that combination therapy with intralesional MA and 50 TCA could accelerate the healing process of CL lesions compared to intralesional MA alone.
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Topical 50 TCA could be suggested as an adjuvant therapy to decrease the healing time of the lesions in patients with cutaneous leishmaniasis.
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| Originating Source
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IRIsfahan University of Medical Sciences
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| publication type
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p
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| Source
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Vice Chancellery for Research
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