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English
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| Material Type
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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51443
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| doc. No
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R2908
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| main entry
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Janghorbani, Mohsen
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| title & author
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Metabolic Syndrome in first degree relatives of patients with type 2 diabetes incidence and risk factors [Research Project]/Executer: Mohsen Janghorbani; ETC: Masoud Amini
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| Publication statement
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Isfahan: Isfahan Medical University, Vice Chancellery for Research, 2011.
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| Physical Description
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no paging.:tab
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| Notes
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This is a research project with project ID 189135 and also is published in " Diabetes and Metabolic syndrome:clinical research and reviews 2011, 201-6"
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| Notes
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First degree relatives (FDRs) of people with type 2 diabetes are at greater cardiovascular and diabetes risk. It is not known whether they are also at greater risk of metabolic syndrome (MetS). The objectives of present study were to assess the incidence of and risk factors for the development of MetS in FDRs of patients with type 2 diabetes. A total of 3217 (842 men and 2375 women) FDRs of consecutive patients with type 2 diabetes aged 30- 70 years in 2003- 2005 were followed through 2010. At baseline participants underwent standard 75 g 2-h standard OGTT and HbA1c measurements. MetS was defined by the NCEP-ATP III. The study group consisted of 734 participants without MetS and history of known diabetes at baseline and had at least one subsequent review in mean (SD) follow-up period of 5.5 (1.2) years. Results: The prevalence of MetS was 35.8 (95 CI: 34.2, 37.5). The incidence of MetS was 4.3 (95 CI: 3.7, 4.9) (4.6 men and 4.2 women) per year. Multivariate analysis revealed that impaired glucose tolerance (IGT) (RR 1.89 (95 CI: 1.28, 2.79)), impaired fasting glucose (IFG) (RR 1.39 (95 CI: 1.10, 1.73)) and lower HDL (RR 1.34 (95 CI: 1.12, 1.60)) were associated with MetS. Conclusions: The findings of this study illustrate for the first time the incidence of MetS in FDRs of patients with type 2 diabetes in Iran. Risk of MetS may increases with IGT, IFG and lower HDL..
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Print
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| Contents
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Complete cure was achieved in 79.2 of MA treated patients and 85.7 patients of the combination therapy group (P>0.05). There was a significant difference in complete cure time between two groups with accelerated healing rate in the combination therapy group.
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Conclusion
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This study showed that combination therapy with intralesional MA and 50 TCA could accelerate the healing process of CL lesions compared to intralesional MA alone.
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Topical 50 TCA could be suggested as an adjuvant therapy to decrease the healing time of the lesions in patients with cutaneous leishmaniasis.
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| descriptor
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Metabolic Syndrome X
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Diabetes Mellitus, Type 2
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Risk Factors
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| Originating Source
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IRIsfahan University of Medical Sciences
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| publication type
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p
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| Source
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Vice Chancellery for Research
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| Ended Date
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2011
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| Project code
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189135
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