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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51452
doc. No : R2961
main entry : Sabzghabaee, Ali Mohammad
title & author : Effect of Hibiscus sabdariffa calices on some Pro- inflammatory factors in Obese Adolescents [Research Project]/Executer: Ali Mohammad Sabzghabaee, Roya Kelishadi, Alireza Ghannadi; ETC: Ehsan Ataei, Sara Arti, Sohila Shirdavani
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2013.
Physical Description : [ No Paging ].:tab. +1 CD-ROM (4 3/4 in.)
Notes : عنوان به فارسی: اثر گلبرگ گیاه ‭(Hibiscus sabdariffa)‬ بر فاکتورهای التهابی مؤثر بر ایجاد و پیشرفت آترواسکلروزیس در نوجوانان.
Notes : We aimed to evaluate the effects of Hibiscus sabdariffa (HS) calices on on Some inflammatory factors (hsCRP, TNF-a, ICAM, VCAM-1, IL-6) in obese adolescents. In this triple blind randomized placebo-controlled clinical trial which was registered in the Iranian registry for clinical trials (IRCT201109122306N2), 90 obese adolescents aged 12-18 years with documented dyslipidemia were randomly assigned in two groups of cases who received 2 grams of fine powdered calices of Hibiscus sabdariffa per day for one month and controls who received placebo powder with the same dietary and physical activity recommendations and duration of exposure. Full lipid profile and fasting blood sugar measured before and after the trial. Proinflammatory factors (heat shock C-reactive Protein, Tumor Necrotizing, factor-a, Intercellular Adhesion Molecule, Vascular Adhesion Molecule -1, Interleukin-6) were measured at the beginning and at the end of the trial. data were analyzed using multivariate general linear model. Overall, 72 participants (mean age of 14.21+- 1.6, 35 boys) completed the trial. The two arms of the study (cases and controls) were not statistically different in terms of age, gender, weight, body mass index (BMI) and lipid profile before the trial. Serum total cholesterol, low density lipoprotein cholesterol and serum triglyceride showed a significant decrease in cases group but high density lipoprotein cholesterol level was not changed significantly. Some pro-inflammatory factors [ICAM, VCAM, TNF-alpha] یhad significant changes in the case group. It is concluded that Hibiscus sabdariffa calyces powder may have significant positive effects on lipid profile of adolescents which maybe attributed to its polyphenolic and antioxidant content. Further studies are needed on dose-response and formulation optimization.
Notes : Print
descriptor : Plants, Medicinal-therapeutic use
: Plant Extracts
: Adolescence
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2013
Project code : 191022
 
 
 
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