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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51456
doc. No : R2984
main entry : Taheriun, Maryam
title & author : Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population [Research Project]/Executer: Maryam Taheriun, Shaghayegh Haghjooy Javanmard, Mohamadhasan Tajaddini, Alireza ZAndifar, Mohammad Saadatnia
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2012.
Physical Description : 5 p.:tab
Notes : عنوان به فارسی: بررسی فراوانی نسبی پلی مورفیسم‭ rs1799864 ( CCR2 Val 64 IIe )‬در ژن‭ ( C- C motif ) receptor- 2‬در بیماران مبتلا به میگرن و مقایسه آن با گروه کنترل
Notes : Background and Objectives.Migraine is amultifactorial common neurovascular disease with a polygenic inheritance. Inflammation plays an important part in migraine pathophysiology. C-C chemokine receptor 2 (CCR2) is an important chemokine formonocyte aggregation and transendothelial monocyte migration. The aim of our study was to investigate the association of migraine with CCR2V64Il polymorphism in the Iranian population. Methods. We assessed 103 patients with newly diagnosed migraine and healthy subjects. Genomic DNA samples were extracted from peripheral blood and genotypes of CCR2V64Il gene polymorphism were determined. For measuring the severity of headache, every patient filled out the MIGSEV questionnaire. Results.There were of significant differences in the distribution of both 64Il allele and heterozygote (GA) genotype of CCR2 gene polymorphism (.. = 0.396; OR = 0.92, 95 CI = 0.50.1.67 and .. = 0.388; OR = 0.91, 95 CI = 0.47.1.73, resp.) between case and control groups.There was no significant difference of alleles frequency between three grades of MIGSEV (.. = 0.922). Conclusions. In conclusion our results revealed no association between CCR2V64Il polymorphism and susceptibility to migraine and also headache severity in the Iranian population..
Notes : Print
descriptor : Receptors, CCR
: Receptors, Chemokine
: Polymorphism, Genetic
: Migraine Disorders
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2013
Project code : 191005
 
 
 
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