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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51470
doc. No : R3011
main entry : Manzouri, Leila
title & author : Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan [Research Project]/Executer: Leila Manzouri, Rasoul Salehi; ETC: Shervin Shariatpanahi, Parisa Rezaie
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2009.
Physical Description : 12 p.:tab
Notes : It was a descriptive study. Systematic random sampling was used for selecting 55 cases of breast cancer and 51 controls of benign breast lesions from the file of Seyedshohada hospital of Isfahan since 2005-2009. A total of 106 paraffin-embedded specimens were selected and HPV DNA was analyzed by polymerase chain reaction and sequenced for different types of HPV in case of positivity for HPV DNA. Data analysis was performed by SPSS 16 software using descriptive statistic, chi-square, and Fisher's exact tests.Human papilloma virus (HPV) DNA has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. Out of 55 malignant and 51 benign breast specimens, 18.2 (10) and 13.7 (7) were positive to HPV DNA, respectively (P = 0.53); 70 (7) malignant and 43 (3) benign breast specimens were positive to high-risk HPV genotypes. In benign specimens, the most common high- and low-risk genotypes were HPV-16 (3.6 ) and HPV-11 (3.6 ), respectively. In benign specimens, the most common high- and low-risk genotypes were HPV-31 (3.9 ) and HPV-43 (3.9 ), respectively. Among malignant and benign specimens, ductal carcinoma and fibro adenoma were the most common lesions positive to different types of HPV, respectively. This study demonstrated the presence of HPV genome in both malignant and benign tumor tissues in women with breast lesions in Isfahan; therefore, further larger epidemiologic studies need to be analyzed to establish the exact role of this virus in the pathogenesis of breast cancer.
Notes : Print
descriptor : Breast Neoplasms
: DNA Probes, HPV
: Papilloma
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2013
Project code : 188126
 
 
 
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