Glycated hemoglobin as a predictor for metabolic syndrome in an Iranian population with normal glucose tolerance

/Executer: Mohsen Janghorban, Masoud Amini

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language of document	:	English
Material Type	:	طرح تحقیقاتی/ پروژه لاتین
Record number	:	51473
doc. No	:	R3022
main entry	:	Janghorban, Mohsen
title & author	:	Glycated hemoglobin as a predictor for metabolic syndrome in an Iranian population with normal glucose tolerance [Research Project]: عنوان به فارسی : هموگلوبین گلیکوزیله به عنوان پیشگویی کننده سندرم متابولیک در یک جمعیت ایرانی با تحمل گلوکز طبیعی/Executer: Mohsen Janghorban, Masoud Amini
Publication statement	:	Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2012.
Physical Description	:	[ No Paging ].:tab
Notes	:	This is accepted as a article in " Metab Syndr Relat Disord. 2012 Dec;10(6):430-6. "
Notes	:	The aim of this study was to determine the ability of glycated hemoglobin (GHb) to predict metabolic syndrome in an Iranian population with normal glucose tolerance (NGT). A cross-sectional study of first-degree relatives (FDRs) of patients with type 2 diabetes was conducted from 2003 to 2005. A total of 1386 FDRs of consecutive patients with type 2 diabetes 30-60 years old (355 men and 1031 women) with NGT were examined. All subjects underwent a standard 75-gram 2-h oral glucose tolerance test and GHb measurement. Consensus criteria in 2009 were used to identify metabolic syndrome. Unadjusted and adjusted multivariate logistic regression analysis was performed to assess the risk of metabolic syndrome. The mean [standard deviation (SD)] age of participants was 42.4 (6.3) years. The prevalence of metabolic syndrome was 17.5 percent in men and 21.5 percent in women. The multivariate-adjusted odds ratio (95 percent CI) of metabolic syndrome was 2.01 (1.03, 3.93) for the highest quintile of GHb compared with lowest quintile. These data indicate that GHb was associated with metabolic syndrome, independently of gender among FDRs of patients with type 2 diabetes with NGT. These data indicate that GHb below the level for prediabetes might be a predictive measure of metabolic syndrome in FDRs of patients with type 2 diabetes with NGT.
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descriptor	:	1. Diabetes Mellitus.- Descriptors: Diabetes Mellitus- complications
	:	Metabolic Diseases
	:	Hemoglobin A, Glycosylated
	:	Glucose Tolerance Test
Originating Source	:	IRIsfahan University of Medical Sciences
publication type	:	p
Source	:	Vice Chancellery for Research
Ended Date	:	2012
Project code	:	191085