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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51480
doc. No : R3037
main entry : Ghahdarijani, Kian Heshmat
title & author : The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery [Research Project]/Executer: Kian Heshmat Ghahdarijani; ETC: Shaghayegh Haghjoo Javanmard, Mohsen Mir Mohammad Sadeghi, Ali Sonbolestan, Amin Ziaei
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2011.
Physical Description : [No paging].:tab
Notes : عنوان به فارسی : بررسی اثر مصرف ملاتونین در عملکرد اندوتلیوم در بیماران مبتلا به بیماری عروق کرونر
Notes : During and after coronary artery bypass grafting (CABG), oxidative stress occurs. Finding an effective way to improveantioxidant response is important in CABG surgery. It has been shown that patients with coronary heart disease have a low Melatonin production rate. The present study aimed to investigate the effects ofMelatoninon nuclear erythroid 2-related factor 2(Nrf2) activity in patients undergoing CABG surgery. Thirty volunteers undergoing CABG were randomized to receive 10?mg oral Melatonin (Melatonin group, ) or placebo (placebo group, ) before sleeping for 1 month before surgery. The activatedNrf2 was measured twice by DNA-based ELISA method in the nuclear extract of peripheral blood mononuclear cells of patients before aortic clumps and 45 minutes after CABG operation. Melatonin administration was associated with a significantincrease in both plasma levels of Melatonin and Nrf2 concentration in Melatonin group compared to placebo group, respectively ( pmol/L, versus pmol/L, , ). The findings of the present study provide preliminary data suggesting that Melatoninmay play a significant role in the potentiation of the antioxidant defense and attenuate cellular damages resulting from CABG surgery via theNrf2 pathway.
Notes : Print
descriptor : Coronary Artery Bypass
: Melatonin
: Vascular Endothelial Growth Factor A
: NF-E2-Related Factor 2
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2011
Project code : 288235
 
 
 
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