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" Synergistic effects of genetic polymorphism and air pollution on markers of endothelial dysfunction in children "
/Executer: Roya Kelishadi
; ETC: Shaghayegh Haghjooy Javanmard, Laleh Rafiei, Parinaz Poursafa
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English
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| Material Type
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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51481
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| doc. No
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R3035
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| main entry
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Kelishadi, Roya
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| title & author
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Synergistic effects of genetic polymorphism and air pollution on markers of endothelial dysfunction in children [Research Project]/Executer: Roya Kelishadi; ETC: Shaghayegh Haghjooy Javanmard, Laleh Rafiei, Parinaz Poursafa
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| Publication statement
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Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2012.
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| Physical Description
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[ No paging].:tab
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| Notes
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عنوان به فارسی : بررسی پلی مورفیسم ژنتیکی G- 33Aو 5466A>Gبه ترتیب در پروموتر ژن ترومبودولین و ژن فاکتور محیطی در ارتباط سطح آلودگی هوا با عوامل زمینه ساز بیماری های قلبی عروقی در نوجوانان ۱۲ - ۱۸ ساله در شهر اصفهان
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This study aims to determine the association of some genetic polymorphisms in the relationship of air pollutants on the serum levels of thrombomodulin (TM) and tissue factor (TF) in a population-based sample of children and adolescents. This cross-sectional study was conducted among 110 participants (52.8 percent girls) with a mean age of 12.7 + 2.3 years, in Isfahan, Iran. Genotypes of TM G33-A and + 5466A > G polymorphisms were determined by the polymerase chain reaction ت restriction length fragment polymorphism method (PCR-RFLP). The enzyme-linked immunosorbent assay (ELISA) was used for measurement of serum TM and TF. The following genotypes were identified for TM: GG in 69.2 percent, GA in27.2 percent, and AA in 3.6 percent of the participants. Considering TF, 108 participants were homozygous for the + 5466A allele, and two subjects had + 5466AG genotype. The mean pollution standards index (PSI) value was at a moderate level; the mean particulate matter measured up to 10 إm (PM10); and ozone (O3), nitrogen dioxide, and sulfur dioxide were considerably high. The mean serum TF and TM levels were not significantly different among the participants with the aforementioned genotypes. Among participants exposed to high quartiles of O3, PM10, and PSI, the TM-33G / A polymorphism (GA + AA genotype) increased the Odds ratio (OR) of the low serum TM level. There was no statistically significant association in the areas of low pollution. The findings of our study support the synergistic effect of the TM-33G / A polymorphism and air pollutants on factors associated with the onset of the atherosclerosis. This might be confirmatory evidence for gene-environment interaction, and related effects on atherogenesis from early life.
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| Notes
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Print
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| descriptor
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Coronary Artery Disease
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Atherosclerosis
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Air Pollution
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Risk Factors
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Life Style
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Adolescence
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Polymorphism, Genetic
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| Originating Source
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IRIsfahan University of Medical Sciences
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| publication type
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p
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| Source
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Vice Chancellery for Research
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| Ended Date
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2012
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| Project code
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290067
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