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| language of document
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English
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| Material Type
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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51487
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| doc. No
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R3150
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| main entry
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Khazaei, Majid
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| title & author
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Effect of ghrelin on number and size of adipocyte cells and fatty streak formation in aorta in obese and normal male mice [Research Project]/Executer: Majid Khazaei; ETC: Bahman Rashidi, Zoya Taher Gorabi
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| Publication statement
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Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research , 2014.
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| Physical Description
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13, 13 p.:tab
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| Notes
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این طرح شامل دو مقاله فارسی و انگلیسی می باشد. عنوان به فارسی : اثر گرلین بر تعداد و اندازه آدیپوسیت و میزان تشکیل رگه های چربی در آئورت موش های نر چاق و نرمال
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| Notes
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Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with 100 mg/Kg subcutaneously, bid) and obese+ghrelin (n=6 each). After 10 days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. Adipocyte cell number, size and aortic intima-media thickness were evaluated. Ghrelin did not change adipocyte cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of adipocyte cells while increased their size (P<0.05). Ghrelin administration had no significant effect on adipocyte cell number and size in obese and control groups (P >0.05). In addition, it could not alter aortic intima-media thickness in both groups. Although ghrelin has several cardiovascular effects, it seems that it could not alter the size and number of adipocyte cells and aortic intima-media thickness in diet-induced obese mice..
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| Notes
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Print
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| descriptor
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Obesity
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Ghrelin
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Peptide Hormones
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Atherosclerosis
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Ischemia
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Carotid Intima-Media Thickness
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Adipocytes
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| Originating Source
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IRIsfahan University of Medical Sciences
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| publication type
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p
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| Source
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Vice Chancellery for Research
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| Ended Date
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2014
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| Project code
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191062
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http://elib.mui.ac.ir/site/catalogue/51487
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