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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51488
doc. No : R3149
main entry : Khazaei, Majid
title & author : Plug and hindlimb ischemia in effect of ghrelin in two models of angiogenesis matrigel obese and normal male mice [Research Project]/Executer: Majid Khazaei; ETC: Bahman Rashidi, Zoya Taher Gorabi
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research , 2013.
Physical Description : various pages.:tab
Notes : این طرح شامل چند مقاله انگلیسی می باشد. عنوان به فارسی : اثر گرلین بر آنژیوژنزیس در دو مدل‭ matrigel‬و‭ hindlimb‬موش های نر چاق و نرمال
Notes : Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with 100 mg/Kg subcutaneously, bid) and obese+ghrelin (n=6 each). After 10 days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. Adipocyte cell number, size and aortic intima-media thickness were evaluated. Ghrelin did not change adipocyte cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of adipocyte cells while increased their size (P<0.05). Ghrelin administration had no significant effect on adipocyte cell number and size in obese and control groups (P >0.05). In addition, it could not alter aortic intima-media thickness in both groups. Although ghrelin has several cardiovascular effects, it seems that it could not alter the size and number of adipocyte cells and aortic intima-media thickness in diet-induced obese mice..
Notes : Print
descriptor : Obesity
: Ghrelin
: Peptide Hormones
: Angiogenesis Inhibitors
: Ischemia
: Hindlimb
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2013
Project code : 189142
 
 
 
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