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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51489
doc. No : R3148
main entry : Khazaei, Majid
title & author : Effect ofsystemic ghrelin administration on coronary angiogenesis in normal and diet- induced obese mice [Research Project]/Executer: Majid Khazaei; ETC: Bahman Rashidi, Zoya Taher Gorabi
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research , 2014.
Physical Description : 9, 5 p.:tab
Notes : عنوان به فارسی : اثر تجویز گرلین سیستمیک بر آنژیوژنز رگ های کرونر قلب در موش های نر چاق و نرمال
Notes : Ghrelin a 28 amino acids peptide that initially was recognized as an endogenous ligand for growth hormone secretagogue receptor (GHSR) however recently, a number of studies demonstrated that it is a cardiovascular hormone with series cardiovascular effects. The main objective of this study was to investigate the effect of systemic ghrelin administration on angiogenesis in the heart and its correlation with serum leptin levels in normal and diet-induced obese mice.24 male C57BL/6 mice were randomly divided into four groups: normal diet (ND) or control, ND+ghrelin, high-fat-diet (HFD) or obese and HFD+ghrelin (n=6/group). Obese and control groups received either HFD or ND for 14 weeks. Then, the ghrelin was injected subcutaneously 100 mg/kg twice daily. After 10 days, the animals were sacrificed, blood samples were taken and the heart was removed. The angiogenic response in the heart was assessed by immunohisochemical staining. HFD significantly increased angiogenesis in the heart expressed as the number of CD31 positive cells than standard diet. Ghrelin did not alter angiogenesis in the heart in both obese and control groups, however, it reduced serum nitric oxide (NO) and leptin levels in obese mice. There was a strong positive correlation between the number of CD31 positive cells and serum leptin concentration (r=0.74). leptin as an angiogenic factor has a positive correlation with angiogenesis in the heart. Although systemic administration of ghrelin reduced serum leptin and NO levels in obese mice, however, it could not alter coronary angiogenesis.
Notes : Print
descriptor : Obesity
: Ghrelin
: Peptide Hormones
: Ischemia
: Angiogenesis Inhibitors
: Coronary Vessels
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2014
Project code : 191063
 
 
 
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