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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51492
doc. No : R3138
main entry : Hashemipour, Mahin
title & author : Intelligence quotient in children with congenital hypothyroidism: The effect of diagnostic and treatment variables [Research Project]/Executer: Mahin Hashemipour, Badredin Najmi; ETC: Nasrin Masaeli, Masoud Amini, Akbar Hasanzadeh, Mahnaz Sartippour
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research , 2013.
Physical Description : Various Paging.:tab
Notes : عنوان به فارسی : بررسی کارکردهای شناختی مبتلایان به هیپوتیروئیدی مادرزادی و ارتباط آن با برخی از عوامل تشخیصی، درمانی
Notes : Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the intelligence quotient (IQ) of children with CH and the effect of diagnostic and treatment variables on it were investigated during the CH screening program. MATERIALS AND METHODS: A total of 120 children in three studied groups were studied in this comparative study the IQ score, in three subsets of verbal IQ, performance IQ and full scale IQ, of children diagnosed with transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH) was measured using revised Wechsler pre-school and primary scale of intelligence and compared with the control group. The relation between IQ score with time of treatment initiation and screening thyroid stimulating hormone (TSH) level was evaluated in all studied groups. Mean of verbal IQ, performance IQ, and full scale IQ score was significantly higher in the control group than CH patients (both permanent and transient) In PCH patients though it was not significant, there was a negative relationship between verbal IQ, performance IQ and full scale IQ and screening TSH and age of treatment initiation. In TCH patients, there was negative and significant relationship between verbal IQ (r = -0.40) and full scale IQ (r = -0.38) and age of treatment initiation (r = -0.46). CONCLUSION: Mean IQ score in both PCH and TCH patients were lower than the control group, which correlates negatively with treatment initiation time. Though CH screening and early treatment has improved the prognosis of patients, but early and high dose of treatment in children with CH is recommended.
Notes : Print
descriptor : Congenital Hypothyroidism
: Intelligence
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2013
Project code : 185173
 
 
 
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