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language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 51497
doc. No : R3143
main entry : Sadeghi, Masoumeh
title & author : Effect of cardiac rehabilitation on inflammatory markers: a systematic review and meta- analysis [Research Project]/Executer: Masoumeh Sadeghi; ETC: Hosein Khosravi Borojeni, Hamid Reza Rohafza, Zahra Kasaei, Safora Yazdekhasti
Publication statement : Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research , 2014.
Physical Description : No Paging.:tab
Notes : Data about the effect of cardiac rehabilitation (CR) on inflammation are contradictory. The present systematic review and meta-analysis was conducted to assess the effect of CR on serum C-reactive protein (CRP) as an indicator of inflammatory state and predictor of recurrent cardiovascular events. Methods: PubMed, SCOPUS, Cochrane library and Google Scholar database were searched up to January 2014 for original articles investigated the effect of CR on c-reactive protein among adult patients with previous cardiovascular events. Random effects model was used to assess the overall effect of cardiac rehabilitation on the change in serum CRP levels. Results: 15 studies met criteria to be included in the present syatematic review and meta-analysis. Our analysis showed that the CR might significantly reduce hsCRP levels (Difference in means (DM)=-1.81 mg/L, 95 percent confidence interval (CI):-2.65,-0.98; P=0.004); however, the heterogeneity between studies was significant (Cochrane Q test, P<0.001, I-squared=84.9 percent). To find the source of variation, we categorized the studies based on studies' design (quality) and duration. We found that, the negative effect was higher among studies which followed their participants for 3 weeks or lower (DM=-2.75 mg/L, 95 percent CI: -3.86,-1.64; P<0.001) compared to studies which investigated the CR effect for 3-8 weeks (DM=-0.89 mg/L, 95 percent CI: -1.35,-0.44; P<0.001) and those lasted more than 8 weeks (DM=-1.71 mg/L, 95 percnet CI: -2.53,-0.89; P<0.001). There was no evidence of heterogeneity when we categorized included studies based on their follow-up period. Conclusion: Both short and long term CR have resulted in improvement in serum hsCRP levels. CR can be perceived as a beneficial tool to reduce inflammatory markers among patients with previous cardiac events. Future studies to explore if the CR affects other inflammatory markers and assessing how dependant the changes in inflammatory markers as a result of cardiac rehabilitation are to the magnitude of the change in body composition, are highly recommended.
Notes : Print
descriptor : Heart Diseases- rehabilitation
: Inflammation
: C -Reactive Protein
Originating Source : IRIsfahan University of Medical Sciences
publication type : p
Source : Vice Chancellery for Research
Ended Date : 2014
Project code : 191175
 
 
 
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