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| language of document
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English
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| Material Type
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طرح تحقیقاتی/ پروژه لاتین
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| Record number
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51499
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| doc. No
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R3158
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| main entry
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Varshosaz, Jaleh
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| title & author
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Production and Optimization of valproic acid nanostructured lipid carriers by the Taguchi design [Research Project]/Executer: Jaleh Varshosaz, Sharareh Eskandari and Majid Tabakhian
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| Publication statement
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Isfahan: Isfahan University of Medical Sciences, Vice Chancellery for Research, 2010.
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| Physical Description
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[ No paging ].:ill, diag, tab
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| Notes
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عنوان به فارسی : تهیه و ارزیابی نانوذرات لیپیدی داخل بینی والپروئیک اسید به روش امولسیون سازی با دیفیوژن حلال
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| Notes
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The objective of this study was production of nanostructured lipid carriers (NLC) of valproic acid for brain delivery thought the nasal pathway. NLC were prepared by solvent diffusion method using a Taguchi design. The lipid, oil and valproic acid were dissolved in organic phase then dispersed in aqueous phase containing the surfactant. The most effective factors on size were surfactant concentration, organic/aqueous phase ratio and acetone/ethanol volume ratio. Zeta potential was more affected by the lipid type, while the surfactant concentration and sonication time were more effective variables on drug release rate. The entrapment efficiency was more affected by lipid/drug weight ratio. Optimum formulation obtained with 400 mg lipid, 400 mg valproic acid, 2 percent surfactant, 1:5 organic/aqueous phase ratio, 1:1 acetone/ethanol volume ratio and 2 min sonication.
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| Notes
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Print
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| descriptor
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Valproic Acid
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Drug Evaluation
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Nanoparticles
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Freeze Drying
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| Originating Source
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IRIsfahan University of Medical Sciences
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| publication type
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p
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| Source
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Vice Chancellery for Research
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| Ended Date
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2010
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| Project code
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185134
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http://elib.mui.ac.ir/site/catalogue/51499
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